Shaun’s proposed treatment for a homeless patient puts him and Dr. Kalu in Dr. Andrews' crosshairs. Claire tries to overcome Dr. Melendez's reluctance to do a risky heart operation. Dr. Glassman faces a difficult decision about his health.
- Will Yun Lee, Fiona Gubelmann, Christina Chang and Paige Spara are promoted to series regulars.
- This marks Chuku Modu's final appearance as a series regular.